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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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447
Regulation of PD-L1 Expression by Nuclear Receptors
Yoshimitsu Kiriyama1,2, Hiromi Nochi1
1Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 769-2193, Kagawa, Japan.
International Journal of Molecular Sciences
|June 28, 2023
Summary
Nuclear receptors regulate programmed cell death ligand 1 (PD-L1) expression, impacting cancer immune evasion. Understanding this regulation is key to developing new cancer immunotherapies.
Area of Science:
- Immunology
- Molecular Biology
- Oncology
Background:
- Immune suppression prevents self-injury but aids cancer growth.
- Programmed cell death 1 (PD-1) and its ligand PD-L1 inhibit T cell responses.
- PD-L1 is expressed in various cancers and normal tissues, promoting immune escape.
Purpose of the Study:
- To review the regulation of PD-L1 expression.
- To focus on the role of nuclear receptors in PD-L1 regulation.
Main Methods:
- Literature review of PD-L1 expression and regulation.
- Analysis of PD-L1 upregulation by cytokines and transcription factors.
- Examination of nuclear receptor control over PD-L1.
Main Results:
- PD-L1 expression is upregulated by inflammatory signals.
- Nuclear receptors including androgen receptor, estrogen receptor, PPARγ, and RORγ regulate PD-L1.
- PD-L1 is expressed in multiple cancer types and normal tissues.
Conclusions:
- Nuclear receptors play a significant role in controlling PD-L1 expression.
- Targeting nuclear receptor regulation of PD-L1 may offer novel cancer therapy strategies.
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