A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
Alexander V Aksenov1, Dmitrii A Aksenov1, Igor A Kurenkov1
1Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.
Abstract:
The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.
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