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Cost-Effectiveness Analysis of Personalized Hypertension Prevention
Sen-Te Wang1,2, Ting-Yu Lin3, Tony Hsiu-Hsi Chen3
1Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Journal of Personalized Medicine
|June 28, 2023
Summary
Personalized hypertension prevention is more cost-effective than standard care. This tailored approach, combining lifestyle changes and medication, offers better value for improving public health outcomes.
Area of Science:
- Health economics
- Preventive medicine
- Cardiovascular disease research
Background:
- Hypertension prevention strategies include population-wide lifestyle changes and high-risk pharmacological interventions.
- A personalized medicine approach, integrating both strategies, is gaining traction but lacks cost-effectiveness analysis.
- Economic evaluation is crucial for implementing tailored preventative methods.
Purpose of the Study:
- To develop a Markov decision model for economic analysis of hypertension prevention strategies.
- To compare the cost-effectiveness of usual care, universal, high-risk, and personalized prevention approaches.
- To assess the financial viability of personalized hypertension prevention.
Main Methods:
- A four-state Markov decision model simulating the natural history of hypertension.
- Economic analysis of four strategies: usual care, universal, high-risk, and personalized.
- Probabilistic cost-effectiveness analysis using Monte Carlo simulation.
- Calculation of incremental cost-effectiveness ratios (ICER) per Quality-Adjusted Life Year (QALY) gained.
Main Results:
- The personalized strategy yielded an ICER of -USD 3317 per QALY gained versus standard care.
- Universal and high-risk strategies had ICERs of USD 120,781 and USD 53,223 per QALY gained, respectively.
- Personalized prevention demonstrated near certainty of cost-effectiveness at a willingness-to-pay threshold of USD 300,000.
Conclusions:
- A personalized, four-state model supports health economic decisions for hypertension prevention.
- Personalized preventive treatment is more cost-effective than conventional, population-based care.
- Findings support evidence-based health decisions for precise hypertension prevention.
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