Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Endocrine Signaling01:45

Endocrine Signaling

64.5K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Interstitial Fluid Compartment: Still Unrecognized or Biophysically Well Described?

Comprehensive Physiology·2026
Same author

The role of pulmonary surfactant on lung fluid balance.

American journal of physiology. Lung cellular and molecular physiology·2025
Same author

Physiopathology of High-Altitude Pulmonary Edema.

High altitude medicine & biology·2024
See all related articles

Related Experiment Video

Updated: Jul 25, 2025

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

10.1K

Early Endothelial Signaling Transduction in Developing Lung Edema.

Giuseppe Miserocchi1

  • 1Department of Medicine and Surgery, Università di Milano Bicocca, 20900 Monza, Italy.

Life (Basel, Switzerland)
|June 28, 2023
PubMed
Summary

Lung endothelial cells adapt to edema by altering membrane rafts. These changes in lipid composition and membrane structures like caveolae and lipid rafts help regulate fluid and gas exchange during conditions like hypoxia and hydraulic edema.

Keywords:
air–blood barriercaveolaefluid loadhypoxialipid raftsplasma membrane

More Related Videos

Engineered Lung Tissues Prepared from Decellularized Lung Slices
08:01

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Published on: January 21, 2022

3.5K
Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

15.6K

Related Experiment Videos

Last Updated: Jul 25, 2025

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

10.1K
Engineered Lung Tissues Prepared from Decellularized Lung Slices
08:01

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Published on: January 21, 2022

3.5K
Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

15.6K

Area of Science:

  • Pulmonary medicine
  • Cell biology
  • Biochemistry

Background:

  • The lung exhibits rapid functional adaptations to edemagenic conditions, counteracting increased microvascular filtration.
  • Endothelial cells play a crucial role in lung fluid balance and gas exchange.

Purpose of the Study:

  • To review evidence for early signaling transduction in lung endothelial cells during edema.
  • To explore the role of membrane rafts in endothelial cell responses to edema.

Main Methods:

  • Review of experimental animal models of lung edema (hypoxia and hydraulic overload).
  • Analysis of changes in endothelial cell plasma membrane composition and structure.

Main Results:

  • Edema triggers early signaling in endothelial cells, involving changes in membrane rafts (caveolae and lipid rafts).
  • Hypoxia leads to endothelial cell thinning, decreased caveolae and AQP-1, and increased lipid rafts, favoring oxygen diffusion.
  • Hydraulic edema causes increased cell volume and opposite changes in membrane rafts, with increased caveolae suggesting fluid reabsorption.

Conclusions:

  • Early changes in endothelial plasma membrane lipid composition may initiate signal transduction during edema.
  • Membrane rafts are critical mobile signaling platforms involved in lung endothelial cell adaptation to edema.
  • Distinct alterations in membrane rafts during hypoxia and hydraulic edema suggest specific adaptive mechanisms for fluid and gas transport.