Related Experiment Video
Updated: Jul 22, 2026
06:41
A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
9.0K
Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases
Marcos Carmona-Rodríguez1, Fernando Moro-Bolado1, Guillermo Romero-Aguilera1
1Servicio de Dermatología, Hospital General Universitario, 13005 Ciudad Real, Spain.
Life (Basel, Switzerland)
|June 28, 2023
Summary
Frontal fibrosing alopecia (FFA) is a scarring condition primarily affecting postmenopausal women. Disease progression correlates with severity, but clinical signs do not predict progression.
Area of Science:
- Dermatology
- Trichology
Background:
- Frontal fibrosing alopecia (FFA) is a progressive scarring alopecia.
- Primarily affects postmenopausal women.
Purpose of the Study:
- To analyze the clinical characteristics, progression, and prevalence of FFA.
- To investigate factors influencing FFA severity and progression.
Main Methods:
- Retrospective, observational, single-center study.
- Inclusion of 306 patients diagnosed with FFA between 2010 and 2021.
- Analysis of disease severity, time of progression, and comorbidities.
Main Results:
- Mean age of onset was 59.5 years.
- Severity was evenly distributed between mild and severe forms.
- Positive correlation between disease severity and time of progression.
- Hypothyroidism present in 22.9% of patients.
- Prevalence estimated at 0.15% and incidence at 15.47 new cases per 100,000 inhabitants.
Conclusions:
- Disease progression in FFA is linked to its severity.
- Clinical signs, including inflammatory trichoscopic signs, are not associated with FFA progression.
Related Concept Videos
01:09Introduction to Fibroblasts
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
01:21Association Areas of the Cortex
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...