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Atopic Dermatitis: Disease Features, Therapeutic Options, and a Multidisciplinary Approach
Liborija Lugović-Mihić1,2, Jelena Meštrović-Štefekov1,2, Ines Potočnjak3
1Department of Dermatovenereology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, Croatia.
Life (Basel, Switzerland)
|June 28, 2023
Summary
Atopic dermatitis (AD) involves skin barrier issues, immune response, and psychological factors. A multidisciplinary approach improves disease control and quality of life for patients and families.
Area of Science:
- Dermatology
- Immunology
- Psychology
Background:
- Atopic dermatitis (AD) pathogenesis involves epidermal barrier dysfunction, altered immune responses, microbial colonization, and psychological factors.
- The inflammatory cascade in AD is characterized by the activation of T helper 2 (Th2) cells, dendritic cells, macrophages, keratinocytes, mast cells, and eosinophils.
Purpose of the Study:
- To review the multifaceted nature of atopic dermatitis (AD) pathogenesis.
- To highlight the importance of a comprehensive, multidisciplinary approach in managing AD.
- To discuss current and emerging therapeutic strategies for AD.
Main Methods:
- Literature review of recent findings on AD pathogenesis.
- Analysis of current therapeutic modalities for AD, including conventional and targeted systemic treatments.
- Examination of the role of psychological factors and comorbidities in AD management.
Main Results:
- AD is driven by a complex interplay of skin barrier defects, immune dysregulation, and external factors.
- Systemic therapies for AD include conventional agents and novel targeted drugs like interleukin inhibitors and JAK inhibitors.
- A multidisciplinary approach involving various medical specialists is crucial for effective AD management.
Conclusions:
- Effective management of atopic dermatitis (AD) necessitates addressing its complex etiology through a coordinated, multidisciplinary strategy.
- Integrated care improves patient adherence, disease control, and overall quality of life.
- Multidisciplinary management optimizes healthcare resource utilization and reduces the socioeconomic burden of AD.
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