Related Experiment Video
Updated: Jul 25, 2025

Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies
Published on: January 26, 2019
The Smallpox Vaccine in Latin America: A New Approach (1801-1804)
Antonio Pérez Pérez1,2, José Ramón Vallejo2
1Área de Anestesiología y Reanimación, Hospital Universitario Puerta del Mar, E-11009 Cádiz, Spain.
Before the famous Balmis Expedition, Spanish Navy surgeons led early global smallpox vaccination efforts. This research highlights their crucial, often overlooked, contributions to eradicating smallpox worldwide.
Area of Science:
- History of Medicine
- Public Health Initiatives
- Epidemiology
Background:
- The Royal Philanthropic Vaccine Expedition is recognized as the first international health expedition for smallpox eradication.
- Historical accounts often overlook earlier, localized vaccination efforts predating the Balmis Expedition.
Purpose of the Study:
- To provide an overview of anti-variolic vaccination initiatives before the Spanish crown-funded Balmis Expedition.
- To highlight the contributions of Spanish Navy surgeons in early smallpox vaccination campaigns.
Main Methods:
- Employs heuristic and hermeneutic methods.
- Utilizes primary sources contrasted with specialized literature.
- Presents findings in a narrative style focusing on individual surgeons.
Main Results:
- Identifies numerous Spanish Navy surgeons who independently introduced smallpox vaccine to various global locations.
- Details specific surgeons and their contributions in Puerto Rico, Colombia, Venezuela, Cuba, New Granada, Guatemala, New Spain, Peru, Río de la Plata, Chile, and the Philippines.
- Demonstrates that the vaccine spread through the initiative of these professionals before the Balmis Expedition.
Conclusions:
- Spanish Navy surgeons played a pivotal role in the early global dissemination of smallpox vaccination.
- These pre-Balmis initiatives, largely driven by individual professionals, were crucial for smallpox control.
- The study offers a new historiographical perspective emphasizing personal actions of medical professionals trained at institutions like the Medical-Surgical School of Cadiz.
More Related Videos
Related Concept Videos
Vaccinations
History of Microbiology
Cross-reactivity
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Microorganisms in Medicine and Therapeutics

