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Updated: Jul 25, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

Efficient Lithium-Based Upconversion Nanoparticles for Single-Particle Imaging and Temperature Sensing.

Yahya A Alzahrani¹, Abdulaziz Alromaeh², Masfer Alkahtani¹

¹Future Energy Technologies Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.

Materials (Basel, Switzerland)

|June 28, 2023

Summary

This summary is machine-generated.

Small YLiF₄:Yb,Er upconversion nanoparticles (UCNPs) enable sensitive single-particle bioimaging and optical temperature sensing. These efficient UCNPs outperform traditional probes, offering new possibilities for advanced bio-applications.

Keywords:

quantum sensing single-particle imaging temperature upconversion nanoparticles

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Related Experiment Videos

Last Updated: Jul 25, 2025

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Published on: November 10, 2017

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Published on: February 20, 2016

Area of Science:

Materials Science
Nanotechnology
Biomedical Optics

Background:

Upconversion Nanoparticles (UCNPs) show promise for biofluorescence imaging and quantum sensing.
Current applications often use ensembles of UCNPs, limiting resolution and sensitivity.
Single-particle analysis is crucial for understanding UCNP behavior and maximizing their potential.

Purpose of the Study:

Synthesize small and efficient YLiF₄:Yb,Er UCNPs for single-particle applications.
Evaluate the performance of these UCNPs in bioimaging and optical temperature sensing.
Compare UCNP performance against conventional probes like quantum dots (QDs) and organic dyes.

Main Methods:

Synthesis of YLiF₄:Yb,Er UCNPs.
Single-particle imaging and photoluminescence measurements.
Optical temperature sensing experiments at the single-particle level.
Comparative analysis with QDs and organic dyes under identical conditions.

Main Results:

Achieved bright and photostable upconversion emission from individual UCNPs.
Demonstrated superior performance (nine times better) compared to QDs and organic dyes at the single-particle level.
Showcased sensitive optical temperature sensing capabilities within the biological temperature range.
Confirmed low laser intensity excitation (20 W/cm²) is sufficient for high-quality signals.

Conclusions:

Small YLiF₄:Yb,Er UCNPs offer excellent optical properties for single-particle imaging.
These UCNPs provide a sensitive platform for optical temperature sensing in biological settings.
The developed UCNPs represent a significant advancement for fluorescent markers in bioimaging and sensing.