Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

898
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
898
Allergic Reactions02:06

Allergic Reactions

27.8K
Overview
27.8K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

357
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
357
Hypersensitivities01:30

Hypersensitivities

799
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
799
Cross-reactivity00:42

Cross-reactivity

31.3K
Overview
31.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrointestinal manifestations during oral immunotherapy: A guide for pediatric allergists.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Acetylsalicylic acid provocation test as the first step in the diagnostic work-up of nonsteroidal anti-inflammatory drugs hypersensitivity reactions in children.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Transient B cell lymphopenia revealed by KRECs newborn screening: Post-screening referral strategies, clinical course, and follow-up.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Characterisation of Allergen Profiles in Commercial Egg Products to Inform Oral Immunotherapy Strategies in Egg Allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Long-Term Effect Of COVID-19 on Children's Lung Function: A Prospective Longitudinal Study.

Pediatric pulmonology·2026
Same author

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026

Related Experiment Video

Updated: Jul 25, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.4K

IgE-Mediated Shellfish Allergy in Children.

Mattia Giovannini1,2, Burcin Beken3, Betul Buyuktiryaki4

  • 1Allergy Unit, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.

Nutrients
|June 28, 2023
PubMed
Summary
This summary is machine-generated.

Shellfish allergy, affecting children, involves IgE and non-IgE reactions. Research is advancing diagnosis and immunotherapy, offering hope for better management of these adverse reactions.

Keywords:
allergenbasophil activation testchildrencomponent-resolved diagnosiscross-reactivitydiagnosisfood allergyimmunotherapyoral food challengeshellfishspecific IgE

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.3K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.4K

Related Experiment Videos

Last Updated: Jul 25, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.4K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.3K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.4K

Area of Science:

  • Food Science
  • Immunology
  • Pediatrics

Background:

  • Shellfish are a valuable protein source, but allergic reactions are increasing.
  • Adverse reactions include immunological (IgE, non-IgE) and non-immunological types.
  • IgE-mediated reactions can cause severe symptoms like anaphylaxis.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, clinical features, diagnosis, and management of shellfish allergies in children.
  • To explore cross-reactivity among shellfish species.
  • To discuss emerging immunotherapeutic approaches.

Main Methods:

  • Literature review of shellfish allergy research.
  • Analysis of epidemiological data.
  • Examination of clinical and diagnostic findings.

Main Results:

  • Key shellfish allergens include tropomyosin, arginine kinase, and myosin light chain.
  • Diagnostic tools and immunotherapeutic strategies are improving but require validation.
  • Cross-reactivity between shellfish types is common.

Conclusions:

  • Shellfish allergy management is evolving with better diagnostics and potential immunotherapies.
  • Further research is needed to validate new treatments for clinical practice.
  • Understanding molecular allergens aids in developing effective allergen immunotherapy.