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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release.

Camila Diedrich¹, Isabella C Zittlau¹, Najeh M Khalil¹

¹Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Guarapuava 85040-167, Brazil.

|June 28, 2023

Summary

This summary is machine-generated.

Chitosan-based nanoemulsions effectively encapsulate luteolin (LUT), enhancing its solubility and enabling controlled release for potential therapeutic applications.

Keywords:

chitosan drug release optimization response surface methodology stability

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Area of Science:

Nanotechnology
Materials Science
Pharmacology

Background:

Luteolin (LUT), a flavonoid with antioxidant, anti-inflammatory, neuroprotective, and antitumor properties, suffers from poor oral absorption due to limited water solubility.
Nanoencapsulation offers a promising strategy to improve the solubility and bioavailability of poorly soluble compounds like LUT.

Purpose of the Study:

To develop and optimize chitosan-based nanoemulsions (NECh-LUT) for the encapsulation of luteolin (LUT).
To characterize the physicochemical properties and stability of the developed nanoemulsions.
To evaluate the in vitro release profile of LUT from the nanoemulsion system.

Main Methods:

Formulation of chitosan-based nanoemulsions (NECh-LUT) using a 2^3 factorial design to optimize oil, water, and surfactant concentrations.
Characterization of nanoemulsions using dynamic light scattering (DLS) for size and polydispersity index (PDI), zeta potential measurements, and transmission electron microscopy (TEM).
Evaluation of encapsulation efficiency, rheological behavior, small-angle X-ray scattering (SAXS), stability studies at room temperature, and in vitro drug release assays.

Main Results:

Optimized NECh-LUT exhibited a mean particle diameter of 67.5 nm, PDI of 0.174, and zeta potential of +12.8 mV, with an encapsulation efficiency of 85.49%.
TEM confirmed spherical morphology, rheological analysis indicated Newtonian behavior, and SAXS revealed bimodal characteristics.
NECh-LUT demonstrated good stability at room temperature for 30 days and sustained LUT release for up to 72 hours.

Conclusions:

Chitosan-based nanoemulsions provide an effective system for encapsulating luteolin, significantly improving its solubility and enabling controlled release.
The optimized NECh-LUT formulation exhibits favorable physicochemical properties, stability, and drug release kinetics.
NECh-LUT holds significant potential as a novel therapeutic option for various disorders requiring luteolin delivery.