Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic effect of Aloe Vera hydrogels with imatinib for pH-responsive drug release in breast cancer treatment.

Drug delivery and translational research·2025
Same author

Dose-dependent toxicological profiling of large-sized ZnO and Co-ZnO nanoparticles: Renal and hepatic implications in Balb/c mice.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2025
Same author

Unlocking the full potential of piperine-loaded nanocarriers for cancer treatment.

Therapeutic delivery·2025
Same author

Inhalable N-Acetylcysteine-loaded Lactose-coated PLGA Nanoparticles for Tuberculosis Treatment.

Pharmaceutical research·2025
Same author

Impact of chain-length of sulfhydryl-modified surface-decorated surfactants on mucoadhesive nanostructured lipid carriers.

Drug delivery and translational research·2025
Same author

Plant-Based Potential in Diabetes Management: In Vitro Antioxidant, Wound-Healing, and Enzyme Inhibitory Activities of Southern Algarve Species.

Molecules (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jun 27, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

17.9K

Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review.

Cláudia Viegas1,2,3,4, Ana B Patrício3,4, João M Prata3,4

  • 1Center for Marine Sciences (CCMar), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal.

Pharmaceutics
|June 28, 2023
PubMed
Summary

Solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are advanced drug delivery systems. NLCs, a newer generation, offer improved drug loading and stability compared to SLNs.

Keywords:
NLCSLNlipid nanoparticlenanocarriernanoparticle characterizationnanoparticle production

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.7K
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.2K

Related Experiment Videos

Last Updated: Jun 27, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

17.9K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.7K
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.2K

Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are lipid-based nanocarriers for drug delivery.
  • These systems enhance drug solubility, permeability, bioavailability, and offer targeted delivery with low toxicity.
  • NLCs represent a second-generation lipid nanoparticle, distinct from SLNs by their composition matrix.

Purpose of the Study:

  • To systematically review and compare SLNs and NLCs as drug delivery systems.
  • To elucidate the production methodologies, physicochemical characterization, and performance of SLNs and NLCs.
  • To focus on the toxicity concerns associated with these nanocarrier systems.

Main Methods:

  • Comprehensive literature review comparing SLNs and NLCs.
  • Analysis of production techniques for both nanocarrier types.
  • Evaluation of physicochemical properties, in vitro, and in vivo performance data.

Main Results:

  • NLCs incorporate both solid and liquid lipids, enabling higher drug loading capacity than SLNs.
  • NLCs demonstrate enhanced drug release profiles and improved stability.
  • Comparison of in vitro and in vivo data highlights differences in efficacy and residence time.

Conclusions:

  • NLCs offer significant advantages over SLNs in terms of drug loading, release, and stability.
  • Both SLNs and NLCs show promise for enhanced drug delivery, but careful consideration of toxicity is necessary.
  • Further research is warranted to fully understand and optimize these nanocarrier systems for therapeutic applications.