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Formation of Dispersible Taohong Siwu Tablets

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Published on: February 3, 2023

Moisture Behavior of Pharmaceutical Powder during the Tableting Process.

Komlan Koumbogle¹, Ryan Gosselin¹, François Gitzhofer¹

¹Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500 Boulevard de l'Université, Sherbrooke, QC J1K 2R1, Canada.

|June 28, 2023

Summary

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Powder moisture accumulation during tableting can cause tablet sticking. This study simulated and measured moisture behavior, revealing that evaporated moisture at the punch-tablet interface induces capillary forces, leading to sticking.

Area of Science:

Pharmaceutical Sciences
Materials Science
Chemical Engineering

Background:

Tablet sticking is a critical issue in pharmaceutical manufacturing, often linked to powder moisture content.
Understanding powder moisture dynamics during compaction is essential for optimizing the tableting process.

Purpose of the Study:

To investigate the behavior and distribution of moisture within pharmaceutical powder during the compaction phase of tableting.
To elucidate the mechanism by which powder moisture contributes to tablet sticking.

Main Methods:

Finite element analysis (FEA) using COMSOL Multiphysics® 5.6 to simulate powder compaction and predict moisture/temperature evolution.
Experimental validation using near-infrared (NIR) and thermal infrared (TIR) cameras to measure tablet surface temperature and moisture post-ejection.

Keywords:

COMSOL Multiphysics Drucker–Prager cap (DPC)NIR penetration depth Pharmaceutics air and moisture (HAM)compaction finite element analysis heat moisture relative density sticking tableting temperature field

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Partial least squares regression (PLS) for predicting surface moisture content.

Main Results:

FEA simulations predicted moisture evaporation from the powder bed during compaction.
Experimental data showed increased tablet temperature and surface moisture post-compaction, with moisture decreasing over successive tableting runs.
Simulated and measured moisture accumulation at the punch-tablet interface was observed.

Conclusions:

Evaporated moisture accumulates at the punch-tablet interface, potentially forming capillary bridges.
These capillary bridges can generate capillary forces, leading to tablet sticking during the tableting process.
Controlling moisture behavior during compaction is crucial for preventing tablet sticking.