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Rewiring Drug Research and Development through Human Data-Driven Discovery (HD3).

David B Jackson1, Rebecca Racz2, Sarah Kim3

  • 1Molecular Health GmbH, 69115 Heidelberg, Germany.

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|June 28, 2023
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Summary
This summary is machine-generated.

The pharmaceutical industry faces an innovation crisis, with preclinical research often yielding candidates unlikely to succeed in patients. A Human Data-driven Discovery (HD³) approach, integrating existing data, can improve R&D efficiency and accelerate new drug development.

Keywords:
adverse eventsdisease modelingdrug discoveryfunctional genomicsinnovationnetwork analysispolypharmacologysystems pharmacology

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Area of Science:

  • Pharmaceutical Research
  • Drug Discovery
  • Biotechnology

Background:

  • The pharmaceutical industry struggles to translate data into R&D efficiency, leading to a drug development innovation crisis.
  • Traditional preclinical research often introduces drug candidates with low probabilities of patient success into the development pipeline.

Purpose of the Study:

  • To review common issues in pharmaceutical R&D efficiency and propose solutions.
  • To introduce the Human Data-driven Discovery (HD³) paradigm as a strategy to overcome the innovation crisis.

Main Methods:

  • Analysis of industry- and science-related factors contributing to R&D inefficiency.
  • First principles analysis to identify critical issues in preclinical research.
  • Review of proof-of-concept applications for the HD³ paradigm.

Main Results:

  • Preclinical research is identified as a bottleneck, front-loading the pipeline with non-viable candidates.
  • The HD³ paradigm offers a strategic integration of existing data and technology for improved outcomes.
  • HD³ applications demonstrate success in drug safety, repositioning, combination therapy design, and pandemic response.

Conclusions:

  • Rectifying the innovation crisis requires a shift from traditional preclinical models.
  • Adopting a Human Data-driven Discovery (HD³) approach is crucial for enhancing drug discovery.
  • Innovators must lead the transition to human-focused, systems-based drug discovery and research.