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Sorafenib-Based Drug Delivery Systems: Applications and Perspectives
Lingyun Wang1, Meihuan Chen1, Xueguang Ran2
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
Polymers
|June 28, 2023
Summary
Sorafenib (SF) nanodelivery systems improve treatment efficacy for hepatocellular carcinoma (HCC) and other cancers by overcoming drug limitations. These nanoformulations enhance SF delivery, reducing side effects and improving patient outcomes.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery
Background:
- Sorafenib (SF) is an FDA-approved drug for hepatocellular carcinoma (HCC) and renal cell carcinoma, inhibiting tumor growth and angiogenesis.
- Clinical use of SF is limited by poor solubility, low bioavailability, unfavorable pharmacokinetics, and severe side effects.
- Nanocarrier-based nanoformulations offer a strategy to improve SF delivery, efficacy, and safety for cancer treatment.
Purpose of the Study:
- To review advances in sorafenib (SF) nanodelivery systems from 2012 to 2023.
- To summarize design strategies for SF nanoformulations using various carrier types.
- To highlight co-delivery systems and synergistic combinations for enhanced cancer therapy.
Main Methods:
- Systematic review of scientific literature on SF nanodelivery systems.
- Categorization of nanocarriers: natural biomacromolecules, synthetic polymers, mesoporous silica, gold nanoparticles.
- Analysis of co-delivery strategies and synergistic combinations with other agents.
Main Results:
- Various nanocarrier systems (lipids, chitosan, PLGA, gold nanoparticles, etc.) have been developed for SF delivery.
- Co-delivery systems and synergistic combinations show promising results for targeted cancer treatment.
- SF nanoformulations demonstrate potential for improved efficacy and reduced toxicity in preclinical studies.
Conclusions:
- SF nanodelivery systems represent a promising approach to enhance the therapeutic potential of sorafenib.
- Further development is needed to address challenges and optimize SF-based nanomedicines for clinical application.
- Future opportunities lie in targeted delivery, combination therapies, and overcoming formulation hurdles.
Keywords:
hepatocellular carcinoma (HCC)multi-kinase inhibitornano-sized carriersnanodelivery systemssorafenibtumor treatmentMore Related Videos
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