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Symptom-Specific Hospital Contacts in 12-18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort

Selina Kikkenborg Berg1,2, Helle Wallach-Kildemoes1, Line Ryberg Rasmussen1

  • 1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, Denmark.

Vaccines
|June 28, 2023
PubMed

Insights

This study examined COVID-19 vaccine side effects in adolescents. BNT162b2 vaccination showed varied hospital contact rates, with specific symptoms noted in boys and girls post-vaccination.

Area of Science:

  • Pediatric Health
  • Vaccinology
  • Public Health Surveillance

Background:

  • Adolescent vaccination against COVID-19 is crucial for public health.
  • Understanding potential side effects and healthcare utilization post-vaccination is essential.
  • Real-world data on BNT162b2 vaccine effects in adolescents is needed.

Purpose of the Study:

  • To investigate symptom-specific hospital contacts in adolescents (12-18 years) after two doses of the BNT162b2 COVID-19 vaccine.
  • To compare hospital contact rates between vaccinated and unvaccinated adolescent cohorts.
  • To identify potential symptom patterns requiring monitoring post-vaccination.

Main Methods:

  • Register-based real-life cohort study design.
  • Sex and age-matched cohorts of vaccinated and unvaccinated adolescents (May-September 2021).
  • Analysis of symptom-specific hospital contacts (ICD-10 R diagnoses) pre- and post-vaccination.

Main Results:

  • Differences in symptom-specific hospital contacts were observed between vaccinated and unvaccinated adolescents.
  • Higher rates of certain hospital contacts were noted in the vaccinated group, while others were higher in the unvaccinated group.
  • Specific symptoms like unspecific cognition in girls and throat/chest pain in boys warrant monitoring in the initial months post-vaccination.

Conclusions:

  • BNT162b2 vaccination in adolescents is associated with varied patterns of symptom-specific hospital contacts.
  • Monitoring for specific symptoms in vaccinated adolescent boys and girls is recommended in the early post-vaccination period.
  • Assessment of post-vaccination hospital contacts should consider the risks associated with COVID-19 infection itself.

Keywords:
COVID-19children and adolescentssymptomsvaccine

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