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Updated: Aug 4, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
Published on: October 18, 2012
Don't Go Breaking My Heart: Not Your Ordinary Tattoo Reaction
Brian McKenna1, Jack Lee, Shyam Raghavan
1University of Virginia School of Medicine, Charlottesville, VA.
Abstract:
Necrobiosis lipoidica (NL) is a rare, chronic idiopathic granulomatous dermatitis with a somewhat controversial association with diabetes and other systemic diseases. We report a case of NL developing within a polychromic tattoo on the lower leg of a 53-year-old woman. Characteristic histopathologic findings of both active and chronic "burnt-out" NL appeared to originate from the tattoo where red ink was used 13 years prior. To the best of our knowledge, only 3 other cases of tattoo-associated NL have been reported.
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