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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

286
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
286
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
549
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

175
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
175
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

381
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
381
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

281
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
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Association between overweight/obesity and multidrug-resistant tuberculosis.

Jesus Peinado1,2, Leonid Lecca1, Judith Jiménez1

  • 11 Socios en Salud Sucursal Perú, Lima, Perú.

Revista Peruana De Medicina Experimental Y Salud Publica
|June 28, 2023
PubMed
Summary

Overweight and obesity are not linked to multidrug-resistant tuberculosis in patients with prior treatment history. This finding suggests body weight may not impact drug resistance in tuberculosis cases.

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Area of Science:

  • Infectious Diseases
  • Metabolic Health
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge, with multidrug resistance (MDR-TB) complicating treatment outcomes.
  • Overweight and obesity are increasingly prevalent worldwide and may influence immune responses and metabolic processes, potentially affecting infectious disease progression.

Purpose of the Study:

  • To investigate the association between overweight/obesity and the development of multidrug resistance in patients undergoing tuberculosis treatment.
  • To differentiate this association in patients with and without a history of prior tuberculosis treatment.

Main Methods:

  • A cross-sectional study utilizing secondary data from a tuberculosis cohort.
  • Analysis included anthropometric measurements and drug-sensitivity testing data from the baseline visit.
  • The study population comprised new TB cases and those with a history of previous TB treatment.

Main Results:

  • The study analyzed 3,734 new TB cases and 766 patients with a history of tuberculosis treatment.
  • Overweight/obesity was found to have no significant association with multidrug resistance in patients with a history of tuberculosis treatment.
  • The prevalence ratio for this association was 0.97 (95% CI: 0.68-1.38).

Conclusions:

  • Overweight/obesity is not associated with multidrug resistance in tuberculosis patients, even those with a history of treatment.
  • The complex interplay between the immune and metabolic systems, influenced by dynamic factors like weight, may not directly translate to altered drug resistance patterns in TB.