Related Experiment Video
Updated: Jul 25, 2025
07:07
A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
12.5K
Primary esophageal melanoma: a case report
Pooja Patel1, Colton Boudreau1, Samuel Jessula2
1Division of General Surgery, Dalhousie University, Halifax, Nova Scotia, B3H 2Y9, Canada.
Melanoma Management
|June 28, 2023
Summary
This report details a rare case of primary esophageal melanoma in an 80-year-old female. Successful minimally invasive esophagectomy was performed, with no recurrence after 25 months.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Oncology
Background:
- Primary esophageal melanoma is exceptionally rare, with limited documented cases.
- Early diagnosis and prompt management are critical due to the poor prognosis associated with this condition.
Observation:
- An 80-year-old female presented with a year of worsening dysphagia and weight loss.
- Diagnostic investigations confirmed primary esophageal melanoma without detectable metastases.
Findings:
- No targetable markers were identified for systemic therapy.
- The patient underwent successful minimally invasive esophagectomy.
- Postoperative management included endoscopic esophageal dilatations for an anastomotic stricture.
Implications:
- This case highlights the successful surgical management of a rare esophageal malignancy.
- Long-term surveillance is essential for patients with primary esophageal melanoma.
- The case also notes concurrent treatment for lung adenocarcinoma.
Related Concept Videos
01:21Barrett Esophagus-II: Clinical Manifestations and Management
216
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
216
01:30Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
01:21Barrett Esophagus-I: Introduction
134
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
134
01:28Esophageal Perforation-II: Clinical Manifestations and Management
94
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
94
01:22Esophageal Perforation-I: Introduction
130
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
130
01:28Esophageal Varices-II: Clinical Features and Management
99
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
99