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Update in postinfectious bronchiolitis obliterans

Alejandro Teper1, Alejandro J Colom1, Ralf Schubert2

  • 1Respiratory Center, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina.

Pediatric Pulmonology
|June 28, 2023
PubMed

Insights

Postinfectious bronchiolitis obliterans (PiBO) is a severe lung disease from infection, causing irreversible airway obstruction. Further research is needed on its causes, symptoms, and treatment.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Pathology

Background:

  • Postinfectious bronchiolitis obliterans (PiBO) is a rare but severe obstructive lung disease.
  • It results from infectious injury to the lower respiratory tract, often by pathogens like adenovirus and Mycoplasma.
  • PiBO leads to persistent, irreversible airway obstruction with small airway damage.

Purpose of the Study:

  • To review the limited literature on PiBO.
  • To consolidate information regarding the aetiology, clinical presentation, and management of PiBO.
  • To highlight the need for further research into PiBO's outcomes.

Main Methods:

  • Literature review of existing studies on PiBO.
  • Synthesis of data on identified causes, clinical features, and treatments.
  • Analysis of reported patient outcomes.

Main Results:

  • Adenovirus and Mycoplasma are common triggers for PiBO.
  • PiBO is characterized by functional and radiological signs of small airway disease.
  • Significant gaps exist in understanding PiBO's full clinical spectrum and treatment efficacy.

Conclusions:

  • PiBO represents a serious sequela of lower respiratory tract infections.
  • Current knowledge on PiBO's aetiology, clinical course, and treatment is insufficient.
  • More comprehensive studies are essential to improve the diagnosis and management of PiBO.
Keywords:
adenoviruschronic obstructive pulmonary diseaserespiratory failure

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