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Current evidence of biofilms in chronic rhinosinusitis- a microbiological perspective
Arne Koefoed1, Brett Wagner Mackenzie1, Richard Douglas1
1Department of Surgery, The University of Auckland, Grafton, Auckland, New Zealand.
Expert Review of Clinical Immunology
|June 28, 2023
Summary
Bacterial and fungal biofilms contribute to chronic rhinosinusitis (CRS), a persistent sinus inflammation. Improved detection methods are needed to combat these resilient biofilms and enhance treatment for CRS patients.
Area of Science:
- Otorhinolaryngology
- Microbiology
- Immunology
Background:
- Chronic rhinosinusitis (CRS) involves persistent sinus mucosa inflammation (>12 weeks).
- CRS significantly reduces quality-of-life and imposes economic burdens.
- Bacterial and fungal biofilms are implicated as key pathogenic factors in CRS.
Purpose of the Study:
- To review the role of biofilms in chronic rhinosinusitis.
- To examine evidence of sinonasal biofilms and their impact on disease severity.
- To explore the interplay between biofilms and host immune responses in CRS.
Main Methods:
- Literature review of studies on biofilms in chronic rhinosinusitis.
- Analysis of evidence for biofilm presence on sinonasal mucosa.
- Exploration of host-immune interactions with sinonasal biofilms.
Main Results:
- Biofilms are present on sinonasal mucosa and contribute to CRS.
- Biofilm presence is linked to increased disease severity.
- Understanding biofilm-host interactions is crucial for CRS management.
Conclusions:
- Biofilms are significant contributors to chronic rhinosinusitis pathogenesis.
- Current biofilm detection methods are inadequate for clinical use.
- Development of advanced molecular techniques for biofilm detection is essential.
