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Fenoterol in asthma.

G Anderson, E Wilkins, A G Jariwalla

British Journal of Diseases of the Chest

|January 1, 1979

Summary

This summary is machine-generated.

Fenoterol, a beta 2-sympathomimetic bronchodilator, significantly improved lung function in asthma patients compared to placebo. It demonstrated greater efficacy and duration than terbutaline, with minimal side effects.

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Area of Science:

Pharmacology
Respiratory Medicine
Clinical Trials

Background:

Asthma involves reversible airway obstruction.
Beta 2-sympathomimetic bronchodilators are used for asthma management.
Fenoterol and terbutaline are common bronchodilators.

Purpose of the Study:

To compare the efficacy of fenoterol and terbutaline in asthmatic patients.
To evaluate the bronchodilator effects on peak expiratory flow rate (PEFR).
To assess patient-reported symptom relief and side effects.

Main Methods:

Double-blind, cross-over trial design.
17 patients with reversible airway obstruction.
Inhalation of fenoterol (0.4 mg), terbutaline (0.5 mg), and placebo.

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Main Results:

Both fenoterol and terbutaline significantly increased PEFR compared to placebo.
Fenoterol demonstrated a greater increase and longer duration of PEFR response than terbutaline.
Patients reported symptom relief with active bronchodilators; side effects were minimal.

Conclusions:

Fenoterol is an effective bronchodilator for asthma.
Fenoterol may offer superior efficacy and duration compared to terbutaline at the tested doses.
Fenoterol provides symptomatic relief with a favorable safety profile.