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Fibrosing alveolitis: CT-pathologic correlation.

N L Müller, R R Miller, W R Webb

    Radiology
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Computed tomography (CT) aids in diagnosing fibrosing alveolitis by revealing lung parenchymal patterns. High-resolution CT scans improve visualization of fibrosis and cystic changes, guiding surgical lung biopsies.

    Area of Science:

    • Pulmonary Medicine
    • Radiology
    • Pathology

    Background:

    • Fibrosing alveolitis is a progressive lung disease characterized by interstitial fibrosis.
    • Accurate assessment of lung involvement is crucial for diagnosis and management.
    • Open lung biopsy is an invasive procedure often used for definitive diagnosis.

    Purpose of the Study:

    • To evaluate the utility of computed tomography (CT) in characterizing lung involvement in fibrosing alveolitis.
    • To compare the effectiveness of different CT collimation resolutions in visualizing pathological changes.
    • To assess CT's role in guiding open lung biopsy procedures.

    Main Methods:

    • Computed tomography (CT) scans were performed on nine patients with fibrosing alveolitis within 10 days of open lung biopsy.

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  • Standard 1-cm collimation chest scans were obtained for all patients.
  • High-resolution 1.5-mm collimation scans were acquired in the biopsy area for six patients.

    • Main Results:

    • CT demonstrated patchy lung involvement with intermingled reticular patterns and normal lung areas in seven patients.
    • The reticular pattern, associated with 2-4 mm cystic spaces, was more pronounced peripherally and corresponded to irregular fibrosis.
    • High-resolution 1.5-mm collimation scans provided superior visualization of architectural changes compared to 1-cm scans.

    Conclusions:

    • CT is valuable for identifying the pattern and distribution of lung involvement in fibrosing alveolitis.
    • High-resolution CT significantly enhances the depiction of interstitial lung disease features.
    • CT imaging can effectively guide surgeons to optimal biopsy sites, improving diagnostic yield.