Related Experiment Video
Updated: Oct 14, 2026

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Oral microbiota in active and passive states of recurrent aphthous stomatitis: An analysis of case-control studies
Xuan Xiao1, Zhaocheng Shi1, Yuhan Song1
1Department of Oral Mucosa, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Objective:
This study was presented to reveal the most distinct microbial prevalence in recurrent aphthous stomatitis (RAS) lesions compared to healthy controls.
Design:
The case-control studies were selected in electronic databases until Nov 2022 with key search terms, and the eligible publications were screened and analyzed by independent authors.
Results:
A total of 14 studies were identified, which included 531 cases of active states of RAS (AS-RAS), 92 cases of passive states of RAS (PS-RAS) and 372 healthy controls. The most sample pattern was the mucosa swab performed in 8 of 14 studies, biopsies in 3 studies, followed by micro-brush, and saliva. A variety of bacteria in higher or lower abundance were observed in RAS lesions.
Conclusions:
The etiopathogenesis of RAS may not be ascribed to a single pathogen. A possible explanation is that microbial interactions modify immune response or destroy the epithelial integrity, thus contributing to the development of the condition.
Related Concept Videos
The Skin Microbiota
Microbiome of the Eye
The Oral Microbiota
Development of the Oral Microbiota
Microbiota of the Respiratory Tract
Microbiota of the Stomach and Small Intestine

