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The role of microRNA in psoriasis: A review

Xingyu Jiang1,2,3, Rongcan Shi1,2,3, Rui Ma1,3

  • 1Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Experimental Dermatology
|June 29, 2023
PubMed

Insights

MicroRNAs (miRNAs) are key players in psoriasis pathogenesis, regulating immune cells and skin cell processes. Future miRNA-based therapies show promise for treating this chronic inflammatory skin disease.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is a chronic, immune-mediated inflammatory skin disease.
  • Understanding its molecular mechanisms, including coding and non-coding genes, is crucial for effective treatment.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression and are increasingly implicated in psoriasis.

Purpose of the Study:

  • To review current advances in the study of miRNAs in psoriasis pathogenesis.
  • To explore the role of dysregulated miRNAs in keratinocyte and immune cell function in psoriasis.
  • To discuss potential miRNA-based therapeutic strategies for psoriasis.

Main Methods:

  • Literature review of recent studies on miRNAs and psoriasis.
  • Analysis of research on miRNA involvement in keratinocyte proliferation, differentiation, and inflammation.
  • Examination of miRNA influence on immune cells like CD4+ T cells, dendritic cells, and Langerhans cells.

Main Results:

  • Dysregulated miRNAs significantly impact keratinocyte proliferation and differentiation in psoriasis.
  • miRNAs play a critical role in modulating the function of various immune cells involved in psoriasis.
  • Evidence suggests miRNAs are central to the pathogenesis of this complex skin condition.

Conclusions:

  • MicroRNAs are integral to the pathogenesis of psoriasis, affecting both skin cells and immune responses.
  • miRNA-based therapies, including miRNA mimics and antagonists, represent a promising avenue for psoriasis treatment.
  • Further research into miRNAs will enhance our understanding and management of psoriasis.
Keywords:
immune cellkeratinocytemicroRNAspsoriasistopical drug delivery

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