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Updated: Jul 25, 2025

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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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YAP1 and P53 Expression in Papillary Thyroid Carcinoma
Dalia Nabil Abdelhafez1, Maram Mustafa Ayoub1, Samira A Mahmoud1
1Department of Pathology, Faculty of Medicine, Fayoum University, Egypt.
Iranian Journal of Pathology
|June 29, 2023
Summary
YAP1 expression is linked to aggressive features in papillary thyroid carcinoma, suggesting a role in patient prognosis. P53 expression also correlates with tumor size and stage.
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- Papillary thyroid carcinoma is a prevalent endocrine cancer with complex origins.
- YAP1 (Yes-associated protein 1) is an oncogene implicated in various human cancers.
- Understanding YAP1 and p53 roles is crucial for papillary thyroid carcinoma prognosis.
Purpose of the Study:
- To examine YAP1 and p53 immunohistochemical expression in papillary thyroid carcinoma.
- To investigate the association between YAP1/p53 expression and clinicopathological risk factors.
- To assess the potential prognostic value of YAP1 and p53 in papillary thyroid carcinoma.
Main Methods:
- Immunohistochemical assessment of YAP1 and p53 expression.
- Analysis of 60 papillary thyroid carcinoma paraffin-embedded tissue samples.
- Correlation of protein expression with clinicopathological characteristics.
Main Results:
- YAP1 expression detected in 70% of cases, significantly associated with tumor size, stage, focality, lymph node metastasis, and extrathyroidal extension.
- p53 expression detected in 85% of cases, significantly associated with tumor size and stage.
- A significant correlation was found between YAP1 and p53 expression (P=0.009).
Conclusions:
- YAP1 expression correlates with adverse clinicopathological features in papillary thyroid carcinoma.
- YAP1 and p53 expression may influence patient outcomes in papillary thyroid carcinoma.
- Further investigation into YAP1's prognostic impact is warranted.
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