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Related Experiment Video

Updated: Jul 25, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Published on: February 8, 2020

Wilms Tumor.

Amanda F Saltzman¹, Nicholas G Cost², Rodrigo L P Romao³

¹Department of Urology, University of Kentucky, Lexington, KY, USA.

The Urologic Clinics of North America

|June 29, 2023

Summary

This summary is machine-generated.

Wilms tumor (nephroblastoma) is a common childhood kidney cancer. Multimodal therapy has improved survival rates for most patients to over 90%.

Keywords:

Nephrectomy Nephroblastoma Renal tumor Urologic oncology Wilms tumor

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Area of Science:

Pediatric Oncology
Nephrology

Background:

Wilms tumor (nephroblastoma) is the most frequent primary malignant renal tumor in children.
It originates from immature kidney remnants, representing an embryonal tumor.
Approximately 500 new cases are diagnosed annually in the United States.

Purpose of the Study:

To summarize the current understanding and treatment outcomes of Wilms tumor.
To highlight the effectiveness of multimodal therapy in improving patient survival.

Main Methods:

Review of existing literature and clinical data on Wilms tumor.
Analysis of treatment strategies including surgery, chemotherapy, and radiation therapy.
Evaluation of risk stratification protocols in guiding therapy.

Main Results:

Multimodal therapy has significantly improved outcomes for Wilms tumor patients.
Survival rates exceeding 90% are achievable with current treatment protocols.
Risk stratification enables tailored treatment approaches.

Conclusions:

Wilms tumor, while serious, has a high survival rate due to advancements in treatment.
Continued research and adherence to risk-stratified multimodal therapy are crucial for optimal patient outcomes.