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Updated: Jul 25, 2025

Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers
Published on: June 24, 2020
Adhesive creases: bifurcation, morphology and their (apparent) self-similarity
Martin H Essink1, Michiel A J van Limbeek2, Anupam Pandey3
1Physics of Fluids Group, Mesa+ Institute, University of Twente, 7500 AE Enschede, The Netherlands. j.h.snoeijer@utwente.nl.
Abstract:
An elastic material that experiences strong compression parallel to its free surface can exhibit sharp surface folds. Such creases arise due to an instability where a self-contacting fold appears on the surface, often observed in growing tissues or swelling gels. Self-adhesion of the contact is known to affect the bifurcation behavior and morphology of these structures, yet a quantitative description remains elusive. From numerical simulations and an energy analysis we resolve how adhesion quantitatively affects both morphology and bifurcation behavior. It is found that a reduced energy is able to accurately describe the bifurcation, in terms of an effective scaling that collapses the data very well. The model accurately describes how adhesion hinders crease nucleation. Furthermore, we show that the free surface profiles in the presence of surface tension exhibit self-similarity, and can be collapsed onto a universal curve.
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