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Updated: Jul 25, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
[Harmonic oscillations of circadian rhythms come out of the shadows]
Michèle Teboul1, Franck Delaunay1
1Université Côte d'Azur, CNRS, Inserm, institut de biologie Valrose (iBV), Nice, France.
Abstract:
About 40 % of the liver transcriptome display a circadian expression. Recently, harmonic oscillations of the circadian rhythm and independent of the circadian clock have been identified. Transcripts oscillating with a 12h period are involved in fundamental and ubiquitous cellular mechanisms such as proteostasis, lipid metabolism or RNA metabolism. A 12h ultradian oscillator involving the UPR response regulator XBP1, the coactivator SRC-3 and the speckle protein SON has been uncovered. The XBP1 oscillator and the 12h ultradian transcriptome are highly conserved suggesting an early emergence that may date back to a time when the Earth's day was much shorter than 24h.
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