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Published on: September 7, 2018
Ethanol impairs cardiocirculatory function in treated canine hemorrhagic shock
Surgery
|September 1, 1986
Summary
Ethanol impairs recovery from hemorrhagic shock by reducing cardiac function and increasing acidosis. Even after resuscitation, intoxicated dogs showed persistent cardiovascular deficits, suggesting heightened myocardial sensitivity to acidosis.
Area of Science:
- Cardiovascular Physiology
- Toxicology
- Shock Pathophysiology
Background:
- Ethanol consumption can affect cardiac function and regional blood flow.
- Understanding ethanol's impact on shock recovery is crucial for clinical management.
Purpose of the Study:
- To investigate if ethanol-induced cardiac and circulatory changes worsen recovery from hemorrhagic shock after resuscitation.
- To determine the effects of ethanol on cardiovascular function and metabolic status during shock and post-resuscitation.
Main Methods:
- Administered ethanol (3 gm/kg) or saline to dogs, inducing hemorrhagic shock.
- Monitored cardiac function (left ventricular pressure, cardiac output), regional blood flow (coronary blood flow), respiration, and acid-base balance (pH, lactate).
- Assessed cardiovascular parameters and acid-base status during shock and after volume replacement (resuscitation).
Main Results:
- Ethanol increased left ventricular pressure rise, coronary blood flow, and metabolic acidosis.
- Both ethanol and shock impaired cardiovascular function and regional blood flow.
- Post-resuscitation, ethanol-treated dogs exhibited lower cardiac output, stroke volume, and stroke work, with persistent acidosis compared to controls.
Conclusions:
- Ethanol-induced alterations in cardiac function and blood flow impair recovery from hemorrhagic shock.
- Myocardial sensitivity to acidosis may contribute to reduced cardiac function in intoxicated dogs post-shock.
- Shock may exacerbate ethanol-induced pancreatic ischemia, further impairing cardiocirculatory function after resuscitation.
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