Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

588
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
588
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Depression: Overview01:18

Depression: Overview

281
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
281
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

140
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
140
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

277
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
277
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

75
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
75

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo dedifferentiation of human epidermal cells.

Cell biology international·2007
Same author

What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex.

Emotion (Washington, D.C.)·2007
Same author

[Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2007
Same author

Morphology of critical nuclei in solid-state phase transformations.

Physical review letters·2007
Same author

Enhanced cooperative activation effect in the hydrolytic kinetic resolution of epoxides on [Co(salen)] catalysts confined in nanocages.

Angewandte Chemie (International ed. in English)·2007
Same author

[Construction of the three-dimensional finite element model of micro -implant -maxilla].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2007

Related Experiment Video

Updated: Jul 25, 2025

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.3K

Neural plasticity and depression treatment.

Yu-Bing Wang1, Ning-Ning Song2,3, Yu-Qiang Ding2,3

  • 1Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) and Department of Anatomy, Histology and Embryology, Tongji University School of Medicine, Shanghai 200092, China.

IBRO Neuroscience Reports
|June 30, 2023
PubMed
Summary

This review explores how changes in neural plasticity contribute to depression, a common mental disorder. It also examines treatments targeting neural plasticity for managing depression.

Keywords:
DepressionMonoamineNeural circuitNeural plasticityNeurotrophic factorSynapse

More Related Videos

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

100
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.7K

Related Experiment Videos

Last Updated: Jul 25, 2025

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.3K
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

100
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.7K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cell Biology

Background:

  • Depression is a prevalent mental disorder with significant societal and familial burdens.
  • Pathogenesis theories include genetic mutations, monoamine imbalance, HPA axis dysfunction, inflammation, and altered neural plasticity.
  • Neural plasticity changes occur across multiple levels, from brain regions to synapses.

Purpose of the Study:

  • To review recent advancements in understanding neural plasticity alterations in depression.
  • To explore depression treatments that modulate neural plasticity.
  • To provide insights into depression's etiology and novel therapeutic development.

Main Methods:

  • Literature review focusing on studies from the last five years.
  • Analysis of neural plasticity changes at various organizational levels (brain regions, cells, synapses).
  • Synthesis of information on therapeutic interventions targeting neural plasticity.

Main Results:

  • Recent research highlights significant neural plasticity changes in depression.
  • Various treatments demonstrate the potential to modify neural plasticity for therapeutic benefit.
  • Understanding these changes is crucial for advancing depression research.

Conclusions:

  • Neural plasticity is a key factor in depression's pathophysiology.
  • Targeting neural plasticity offers promising avenues for novel depression treatments.
  • Further research into neural plasticity can illuminate depression etiology and treatment strategies.