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Related Experiment Video

Updated: Jul 25, 2025

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

Murine models to study human NK cells in human solid tumors.

Monica Parodi¹, Simonetta Astigiano², Paolo Carrega³

¹Unità Operativa UO Patologia e Immunologia Sperimentale, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Frontiers in Immunology

|June 30, 2023

Summary

Mouse models are essential for studying Natural Killer (NK) cells. Advanced humanized mouse models, like NOG and NSG, are crucial for investigating human NK cell behavior and function in preclinical studies.

Keywords:

human-in-mouse model humanized mice natural killer cells solid tumor tumor immunity

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Area of Science:

Immunology
Cancer Research
Preclinical Models

Background:

Mouse models have been instrumental in understanding Natural Killer (NK) cell development, function, and tissue circulation.
Early studies utilized murine models for murine NK cells, evolving to sophisticated human-in-mice models to study human NK cells.

Purpose of the Study:

To review the evolution of mouse models used for NK cell research.
To highlight the utility of NOG and NSG models for human NK cell studies and therapeutic evaluations.
To discuss the integration of in vivo and in vitro approaches for optimizing preclinical studies.

Main Methods:

Review of historical and current mouse models for NK cell research.
Focus on NOG and NSG models as recipients for humanized tumor models.
Evaluation of enhancers for human NK cell function in vivo.

Main Results:

Mouse models have progressively advanced from studying murine NK cells to investigating human NK cells in humanized settings.
NOG and NSG models are pivotal for creating human-in-mice tumor models and assessing human NK cell activity.
Various enhancers, including cytokines and chimeric molecules, can be evaluated for their impact on human NK cell function.

Conclusions:

Mouse models, particularly humanized NOG and NSG strains, are indispensable tools for NK cell research.
These models facilitate the study of human NK cell behavior, function, and therapeutic interventions in vivo.
Integrating traditional and novel in vivo/in vitro methods will enhance the efficacy of preclinical NK cell studies.