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Inactivation of SARS-CoV-2 on salt-coated surfaces: an in vitro study
Monika Gsell1,2, Xavier Bulliard3, Sandra Schorderet Weber4
1Institute for Infectious Diseases, University of Berne, 3010, Bern, Switzerland. monika.gsell@unibe.ch.
Archives of Microbiology
|June 30, 2023
Summary
Sodium chloride coatings on face masks significantly reduce SARS-CoV-2 virus replication, offering a promising solution to prevent self-contamination from contaminated masks. This antiviral coating is effective for reusable masks.
Area of Science:
- Virology
- Materials Science
- Public Health
Background:
- Face masks are crucial for preventing SARS-CoV-2 transmission via droplets and aerosols.
- Concerns exist regarding self-contamination from SARS-CoV-2 infectious particles on used masks.
- Antiviral coatings offer a potential solution for reusable mask safety.
Purpose of the Study:
- To assess the antiviral properties of sodium chloride coatings on common fabrics.
- To evaluate the effectiveness of salt coatings in preventing SARS-CoV-2 fomite contamination.
- To validate a novel in vitro bioassay for testing antiviral coatings.
Main Methods:
- Developed salt coatings on fabrics using spraying and dipping techniques.
- Utilized a 3D airway epithelial cell culture model and SARS-CoV-2 for in vitro testing.
- Quantified infectious virus particles (plaque-forming units) and viral genome copies over time.
Main Results:
- Sodium chloride coatings significantly reduced SARS-CoV-2 replication compared to uncoated materials.
- Demonstrated the effectiveness of salt coatings in preventing fomite contamination.
- Validated the lung epithelia bioassay for evaluating antiviral coatings.
Conclusions:
- Sodium chloride coatings are effective in reducing SARS-CoV-2 on mask surfaces.
- This method presents a viable strategy for enhancing the safety of reusable face masks.
- The developed bioassay is suitable for future research on novel antiviral materials.
