Related Experiment Video
Updated: Jul 24, 2025
00:08
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
10.1K
Relationship between IgE-mediated allergy and complicated appendicitis in children
Zhiyi Zhang1, Li Wang2, Chuanping Xie1
1Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Pediatric Surgery International
|July 1, 2023
Summary
Children with IgE-mediated allergy have a reduced risk of complicated appendicitis (CA). Allergy did not impact prognosis after appendectomy in this pediatric study.
Area of Science:
- Pediatric Surgery
- Allergy Immunology
- Gastrointestinal Disease
Background:
- Complicated appendicitis (CA) poses significant risks in pediatric patients.
- The role of IgE-mediated allergies in appendicitis outcomes is not well understood.
Purpose of the Study:
- To investigate the association between IgE-mediated allergy and the development of complicated appendicitis (CA).
- To evaluate the impact of IgE-mediated allergy on the prognosis of pediatric patients undergoing appendectomy.
Main Methods:
- Retrospective analysis of 1156 pediatric patients with acute appendicitis (AA).
- Patients were categorized based on the presence or absence of IgE-mediated allergies.
- Logistic regression analysis was employed, adjusting for clinical and laboratory variables to assess the association between allergy and CA.
Main Results:
- 16.0% of patients had IgE-mediated allergies.
- Children with IgE-mediated allergies showed a significantly reduced risk of developing CA (adjusted OR=0.582, P=0.023).
- No significant differences were observed in operative time, length of hospital stay, readmission rates, or adhesive intestinal obstruction between groups.
Conclusions:
- IgE-mediated allergy is associated with a decreased risk of complicated appendicitis in children.
- Allergy status does not appear to influence the post-appendectomy prognosis in this pediatric cohort.
Related Concept Videos
01:22Appendicitis-I: Introduction
265
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
265
01:29Appendicitis-II: Diagnostic Studies and Management
100
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
100
02:06Allergic Reactions
27.8K
Overview
27.8K
01:27Allergic Drug Reactions
898
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
898
01:10Antibody Structure
60.4K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.4K
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K