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Updated: Jul 24, 2025

Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
O-GlcNAcylation: A Crucial Regulator in Cancer-Associated Biological Events
Zhihong Ran1,2,3, Lei Zhang3, Ming Dong3
1Medical College, Three Gorges University, Yichang, 443000, China.
Abstract:
O-GlcNAcylation, a recently discovered post-translational modification of proteins, plays a crucial role in regulating protein structure and function, and is closely associated with multiple diseases. Research has shown that O-GlcNAcylation is abnormally upregulated in most cancers, promoting disease progression. To elucidate the roles of O-GlcNAcylation in cancer, this review summarizes various cancer-associated biological events regulated by O-GlcNAcylation and the corresponding signaling pathways. This work may provide insights for future studies on the function or underlying mechanisms of O-GlcNAcylation in cancer.
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