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[Topical therapy--risks and unwanted effects].

A Zesch

    Zeitschrift Fur Hautkrankheiten
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Topical application of substances differs from other methods, potentially causing chronic skin damage or systemic effects due to absorption. Dermatologists often diagnose these skin changes from long-term topical therapies.

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    Area of Science:

    • Dermatology and Pharmacology
    • Pharmacokinetics of topical agents

    Context:

    • Topical drug administration exhibits distinct kinetics compared to parenteral or oral routes.
    • The stratum corneum's integrity significantly influences percutaneous absorption and potential toxicity.
    • Long-term topical therapies can lead to insidious chronic damage or systemic effects.

    Purpose:

    • To elucidate the pharmacokinetic differences between topical and systemic drug application.
    • To highlight the potential for both local skin damage and systemic toxicity from topical agents.
    • To emphasize the diagnostic role of dermatologists in evaluating skin changes from topical treatments.

    Summary:

    • Percutaneous absorption kinetics differ from oral/parenteral routes, with intact or damaged stratum corneum affecting drug reservoirs and systemic levels.

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  • Chronic, subtle skin damage is more common than acute systemic toxicity from topical substances like salicylic acid.
  • Excipients and supplementary therapies can also contribute to skin alterations, necessitating dermatological assessment.

    • Impact:

    • Understanding these kinetics is crucial for optimizing topical drug efficacy and safety.
    • Highlights the need for careful monitoring in long-term topical therapy regimens.
    • Underscores the importance of considering excipient effects in dermatological treatments.