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NAADP-binding proteins - Linking NAADP signaling to cancer and immunity

Louisa D Heßling1, Berit Troost-Kind1, Mariella Weiß1

  • 1The Calcium Signaling Group, Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Biochimica Et Biophysica Acta. Molecular Cell Research
|July 2, 2023
PubMed

Insights

Nicotinic acid adenine dinucleotide phosphate (NAADP) signaling involves newly identified HN1L/JPT2 and LSM12 proteins. These proteins share oncogenic functions and roles in cancer and immunity pathways, suggesting novel therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Cancer Research
  • Immunology

Background:

  • Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent calcium-mobilizing second messenger.
  • Two NAADP-binding proteins, HN1L/JPT2 and LSM12, were recently identified.
  • ASPDH is also a potential, less selective NAADP-binding partner.

Conclusions:

  • NAADP-binding proteins HN1L/JPT2 and LSM12 play critical roles in cancer development and progression.
  • Shared involvement in cancer and immunity pathways suggests these proteins are key regulators.
  • Understanding these connections may reveal novel therapeutic strategies for cancer and immune-related diseases.
Keywords:
CalciumCancerHN1L/JPT2LSM12NAADPSignaling

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