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Author Spotlight: A Stable Phantom Material for Optical and Acoustic Imaging

Author Spotlight: A Stable Phantom Material for Optical and Acoustic Imaging

Published on: June 16, 2023

A Stable Phantom Material for Optical and Acoustic Imaging.

Lina Hacker¹, Aoife M Ivory², James Joseph³

¹Department of Physics, University of Cambridge; Cancer Research UK Cambridge Institute, University of Cambridge.

Journal of Visualized Experiments : Jove

|July 3, 2023

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This summary is machine-generated.

A new, stable, and affordable tissue-mimicking material was developed for calibrating biomedical imaging devices. This biophotonic phantom material supports standardization across photoacoustic, optical, and ultrasound technologies.

Area of Science:

Biomedical Engineering
Materials Science
Optics and Acoustics

Background:

Standardized biomedical imaging devices are crucial for comparing results across institutions and vendors.
Developing stable, tissue-mimicking phantom materials is essential for the clinical translation of novel imaging technologies.

Purpose of the Study:

To present a manufacturing process for a stable, low-cost, tissue-mimicking material for photoacoustic, optical, and ultrasound standardization.
To enable independent tuning of acoustic and optical properties for versatile phantom applications.

Main Methods:

A copolymer-in-oil material was synthesized using mineral oil and a copolymer.
Acoustic properties (speed of sound, attenuation) and optical properties (absorption, scattering) were characterized.

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Material homogeneity was confirmed using photoacoustic imaging.

Main Results:

The material exhibited a speed of sound of 1,481 ± 0.4 m·s^-1 at 5 MHz and acoustic attenuation of 6.1 ± 0.06 dB·cm^-1 at 5 MHz.
Optical properties included absorption µa(λ) = 0.05 ± 0.005 mm^-1 and scattering µs'(λ) = 1 ± 0.1 mm^-1 at 800 nm.
Independent tuning of acoustic and optical properties was achieved by varying polymer concentration, titanium dioxide, and oil-soluble dye.

Conclusions:

The developed material offers a stable, reproducible, and cost-effective solution for multimodal acoustic-optical standardization.
Its biologically relevant properties and ease of fabrication make it highly promising for advancing biomedical imaging standards.