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Updated: Jul 24, 2025

A Method for Islet Transplantation to the Omentum in Mouse
Published on: January 7, 2019
Omentin-1 and diabetes: more evidence but far from enough
Jing Xu1, Min Li1, Xinli Jiang2
1Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Aims And Background:
Omentin-1 (oment-1) is a type of adipokines that is mainly expressed in visceral fat tissue. Based on accumulating evidence, oment-1 is closely related to diabetes and its complications. However, so far data about oment-1 and diabetes is fragmented. In this review, we focus on the role of oment-1 on diabetes, including its possible signalling pathways, the correlation of circulating omens-1 levels with diabetes and its complications.
Methods:
The web of PubMed was searched for articles of relevant studies published until February, 2023.
Results And Conclusions:
Oment-1 might exert its effects by inhibiting the NF-κB pathway and activating the Akt and AMPK-dependent pathways. The level of circulating oment-1 is negatively correlated with the occurrence of type 2 diabetes and some complications, including diabetic vascular disease, cardiomyopathy, and retinopathy, which can be affected by anti-diabetic therapies. Oment-1 could be a promising marker for screening and targeted therapy for diabetes and its complications; however, more studies are still needed.
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