A 2-dimensional model framework for blood glucose prediction based on iterative learning control architecture

The accurate, timely, and personalized prediction for future blood glucose (BG) levels is undoubtedly needed for further advancement of diabetes management technologies. Human inherent circadian rhythm and regular lifestyle resulting in similarity of daily glycemic dynamics play a positive role in the prediction of blood glucose. Inspired by the iterative learning control (ILC) method in the field of automatic control, a 2-dimensional (2-D) model framework is constructed to predict the future blood glucose levels by taking both the short-range information within a day (intra-day) and long-range information between days (inter-day) into account. In this framework, the radial basis function neural network was applied to capture nonlinear relationships in glycemic metabolism, that is, short-range temporal dependence and long-range contemporaneous dependence on previous days. We build models for each patient, and the models were tested on the in silico datasets at various prediction horizons (PHs). The learning model developed in the 2-D framework successfully increases the accuracy and reduces the delay of predictions. This modeling framework provides a new point of view for BG level prediction and contributes to the development of personalized glucose management, such as hypoglycemia warning and glycemic control.