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Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
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At-line porosity sensing for non-destructive disintegration testing in immediate release tablets.
Prince Bawuah1, Mike Evans2, Ard Lura3
1University of Cambridge, Department of Chemical Engineering and Biotechnology, UK.
International Journal of Pharmaceutics: X
|July 3, 2023
Summary
Automated terahertz spectroscopy offers rapid, non-destructive tablet porosity measurement. This technique correlates porosity with disintegration time, aiding pharmaceutical quality control.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Spectroscopy
Background:
- Tablet porosity is a critical quality attribute influencing drug release and bioavailability.
- Traditional methods for porosity measurement are often destructive and time-consuming.
- Developing rapid, non-destructive techniques is essential for efficient pharmaceutical manufacturing and quality control.
Purpose of the Study:
- To evaluate the utility of at-line terahertz time-domain spectroscopy (THz-TDS) for measuring tablet porosity.
- To investigate the impact of manufacturing parameters (turret speed, compaction pressure) on tablet porosity.
- To establish a predictive model correlating tablet porosity with disintegration time.
Main Methods:
- Utilized fully automated at-line terahertz time-domain spectroscopy (THz-TDS) in transmission mode.
- Prepared and analyzed six batches of 1000 immediate-release tablets each, varying turret speed and compaction pressure.
- Performed destructive disintegration time measurements for model development.
Main Results:
- THz-TDS provided precise and non-destructive measurements of tablet refractive index and porosity.
- Manufacturing parameters significantly influenced tablet porosity, with ranges from 5.5% to 26.5% average porosity.
- A reasonable predictive model for disintegration time based on porosity was developed.
- Tablet properties showed changes after nine months of ambient storage.
Conclusions:
- Automated THz-TDS is a viable tool for rapid, non-destructive at-line monitoring of tablet porosity in pharmaceutical manufacturing.
- Understanding the relationship between manufacturing parameters, porosity, and disintegration time is crucial for tablet quality.
- THz-TDS can detect changes in tablet properties over time, supporting long-term stability assessments.
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