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Updated: Jul 24, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
Imatinib associated temporal bone osteonecrosis
Dominic McKenna1, Ekambar Reddy1
1Craigavon Area Hospital (Southern Health and Social Care Trust) Portadown UK.
Abstract:
Tyrosine kinase inhibitors have substantially improved survival in patients with gastrointestinal stromal tumors (GIST) and chronic myeloid leukemia (CML). We report the first association between long-term imatinib use and temporal bone osteonecrosis, highlighting the importance of prompt ENT evaluation of such patients with new otological symptoms.
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