Related Experiment Video

Updated: Jul 24, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Rictor induces AKT signaling to regulate lymphatic valve formation

Richa Banerjee, Luz A Knauer, Drishya Iyer

    Biorxiv : the Preprint Server for Biology
    |July 3, 2023
    PubMed
    Summary

    Mammalian target of rapamycin complex 2 (mTORC2) signaling, specifically its component RICTOR, is essential for lymphatic valve formation. RICTOR activation of AKT prevents FOXO1 nuclear accumulation, promoting valve development and maintenance.

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