Related Experiment Video
Updated: Jul 24, 2025
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Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
Published on: April 27, 2014
21.8K
Multielectrode Network Stimulation (ME-NETS) demonstrated by concurrent tDCS and fMRI.
Biorxiv : the Preprint Server for Biology
|July 3, 2023
Summary
Multielectrode network stimulation (ME-NETS) using transcranial direct current stimulation (tDCS) effectively modulates brain network connectivity. This approach shows greater reliability and specificity compared to single-electrode stimulation for targeting the Arcuate Fasciculus network.
Area of Science:
- Neuroscience
- Neuroimaging
- Brain Stimulation
Background:
- Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique.
- The capacity of tDCS to reliably alter intrinsic connectivity within large-scale brain networks remains under investigation.
Approach:
- Concurrent tDCS-MRI was employed to assess high-dose anodal tDCS effects on the Arcuate Fasciculus (AF) network connectivity.
- Compared single-electrode stimulation (SE-S) with multielectrode network stimulation (ME-NETS) targeting AF network nodes.
Key Points:
- Both SE-S and ME-NETS increased connectivity within the AF network.
- ME-NETS demonstrated a significantly larger and more reliable modulation effect than SE-S.
- Connectivity modulation by ME-NETS was specific to the targeted AF network, as evidenced by comparison with the Inferior Longitudinal Fasciculus (ILF) network and seed-to-voxel analyses.
Conclusions:
- Multielectrode network stimulation is a superior method for reliably modulating intrinsic brain network connectivity with tDCS.
- tDCS, particularly ME-NETS, can induce immediate and dynamic changes in brain network connectivity.
