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Related Experiment Video

Updated: Jun 13, 2026

Infant Auditory Processing and Event-related Brain Oscillations

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Very Early Cortical Auditory Responses to Speech in Humans.

Karl D Lerud¹, Charlie Fisher², Vrishab Commuri²

¹Institute for Systems Research, University of Maryland, College Park MD 20742.

Biorxiv : the Preprint Server for Biology

|June 12, 2026

Summary

The auditory brainstem response (ABR) and middle latency response (MLR) complex differ between speech and clicks. Naturalistic speech reveals an early cortical peak in auditory processing, enhancing our understanding of auditory system behavior.

Keywords:

ABR EEG MEG MLR SN10 TRF Wave V auditory cortex speech

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Area of Science:

Neuroscience
Auditory Neuroscience
Cognitive Neuroscience

Background:

The auditory brainstem response (ABR) and middle latency response (MLR) complex are fundamental measures of auditory processing.
Understanding how these responses vary with stimulus complexity and behavioral relevance is crucial but not well-established.

Purpose of the Study:

To investigate the differences in auditory brainstem response (ABR) and middle latency response (MLR) complex between click and naturalistic speech stimuli.
To characterize the early cortical peak in auditory processing during speech perception.

Main Methods:

Noninvasive electromagnetic temporal response functions (TRFs) were recorded in healthy young adults.
Source analysis was applied to TRFs elicited by click and naturalistic speech stimuli.

Main Results:

A novel, early cortical peak (11 ms latency) was identified in the TRF's ABR-MLR complex for speech, absent in click responses.
Significant differences in latency and source were observed between speech and click MLR complexes.
Auditory responses reflect the ethological relevance of speech even at short timescales.

Conclusions:

The temporal response function (TRF) framework effectively reveals distinct auditory processing patterns for different stimulus types.
Naturalistic speech elicits unique early cortical activity compared to simple click stimuli.
This study advances our understanding of the human auditory system's dynamic response to complex, behaviorally relevant sounds.