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Related Experiment Video

Updated: Jul 3, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Open millifluidics based on powder-encased channels.

Xiaoguang Li¹, Xianglong Pang¹, Haohao Jiang¹

¹Shaanxi Basic Discipline (Liquid Physics) Research Center, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi 710129, China.

Proceedings of the National Academy of Sciences of the United States of America

|July 3, 2023

Summary

Researchers developed novel all-powder constructs for fluid manipulation, overcoming limitations of traditional millifluidics. These adaptable systems enable flexible reconfiguration and open access for diverse applications in chemistry and biology.

Keywords:

flow manipulation interfacial jamming open millifluidics structured liquids

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Last Updated: Jul 3, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

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Area of Science:

Materials Science
Chemical Engineering
Fluid Dynamics

Background:

Millifluidics offers precise liquid control but uses rigid channels.
Existing methods lack design flexibility and external interaction.
All-liquid constructs are adaptable but confined to liquid environments.

Purpose of the Study:

To introduce a new method for fluid manipulation using powder-encased liquids.
To overcome the design and environmental limitations of current millifluidic systems.
To demonstrate the flexibility and adaptability of these novel constructs.

Main Methods:

Encasing flowing fluids within a hydrophobic powder matrix in air.
Utilizing the jamming property of powders to contain and isolate liquids.
Demonstrating reconfiguration, grafting, and segmentation of the constructs.

Main Results:

Successfully created flexible, adaptable, and open fluidic channels using powder.
Achieved arbitrary connections/disconnections and substance manipulation.
Showcased potential for diverse applications in biological, chemical, and material sciences.

Conclusions:

Powder-contained liquid constructs offer a versatile alternative to traditional millifluidics.
The open nature and adaptability facilitate integration and substance exchange.
This approach unlocks new possibilities for microfluidic device design and experimentation.