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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Recent advances in anticancer peptoids.

Jidan Zhu1, Siyu Chen1, Ziwei Liu1

  • 1Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei 430205, China.

Bioorganic Chemistry
|July 3, 2023
PubMed
Summary
This summary is machine-generated.

Anticancer drug development is crucial due to tumor drug resistance. Peptoids, a class of peptidomimetics, offer promising characteristics for novel anticancer drug development, showing efficacy in various cancer treatments.

Keywords:
Breast cancerLung cancerPeptoid hybridsPeptoidsProstate cancer

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Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Tumor drug resistance necessitates continuous development of novel anticancer agents.
  • Peptoids, a class of peptidomimetics, possess advantageous properties like protease resistance and non-immunogenicity.
  • These characteristics make peptoids suitable for therapeutic applications and drug development.

Purpose of the Study:

  • To review recent advances in the application of peptoids and peptoid hybrids in cancer therapy.
  • To highlight the potential of peptoids as an alternative molecular class for anticancer drug development.
  • To provide a reference for future research in peptoid-based cancer treatments.

Main Methods:

  • Review of recent scientific literature on peptoids and their application in cancer treatment.
  • Analysis of peptoid characteristics relevant to anticancer drug development.
  • Discussion of specific cancer types where peptoids have shown efficacy.

Main Results:

  • Peptoids demonstrate unique properties beneficial for drug development, including protease resistance and non-immunogenicity.
  • Peptoids and their hybrids have shown efficacy in treating various cancers, including prostate, breast, and lung cancer.
  • Recent advances indicate significant progress in utilizing peptoids for cancer therapy.

Conclusions:

  • Peptoids represent a promising molecular category for the development of new anticancer drugs.
  • The unique properties of peptoids offer advantages over traditional peptide-based therapeutics.
  • Further research and development in peptoid-based anticancer drugs are warranted.