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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Glucose-Responsive Fibrin Hydrogel-Based Multimodal Nucleic Acid Delivery System.

Mangesh Morey1, Aitor Larrañaga1, Sunny Akogwu Abbah1

  • 1CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland.

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|July 4, 2023
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Summary

This study presents a novel glucose-responsive hydrogel for diabetic wound healing. The system effectively delivers nucleic acids, promoting healing and reducing inflammation without side effects.

Keywords:
biomaterialsdrug deliveryfibringlucose-responsivemicrocapsulesmicroparticlesnucleic acidswound healing

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Area of Science:

  • Biomaterials Science
  • Gene Therapy
  • Wound Healing Research

Background:

  • Nucleic acid therapy offers potential for wound healing via gene expression modification.
  • Challenges include nucleic acid protection, bioresponsive delivery, and cellular transfection.
  • A glucose-responsive system is ideal for diabetic wound treatment, enabling regulated delivery.

Purpose of the Study:

  • To design and evaluate a glucose-responsive gene delivery system for diabetic wounds.
  • To assess the system's ability to load and release nucleic acids effectively and safely.
  • To investigate the therapeutic effects of the system on wound healing in a diabetic mouse model.

Main Methods:

  • Fabrication of fibrin-coated polymeric microcapsules (FCPMC) using a layer-by-layer approach.
  • Loading of nucleic acids into polyplexes within the FCPMC system.
  • In vitro cytotoxicity assessment and in vivo studies on diabetic db/db mice wounds.

Main Results:

  • The FCPMC system efficiently loaded and sustained nucleic acid release with no observed cytotoxicity.
  • In vivo application to diabetic wounds showed improved reepithelialization and angiogenesis.
  • The system significantly decreased inflammation and upregulated key wound healing proteins (Actn2, MYBPC1, desmin).

Conclusions:

  • The developed glucose-responsive fibrin hydrogel (GRFHG) effectively promotes wound healing in a diabetic context.
  • The system demonstrates potential for co-delivery of multiple therapeutic nucleic acids.
  • This biomaterial offers a promising strategy for managing diabetic wound complications.