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Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
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Shaping mitochondria through fed-fast and circadian cycles
Subhash Khatri1, Rubina Kazi1, Ullas Kolthur-Seetharam1,2
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
The Biochemical Journal
|July 4, 2023
Summary
Mitochondria are crucial for maintaining metabolic balance by responding to feeding and circadian rhythms. Understanding how mitochondria remodel during these cycles is key to metabolic health.
Area of Science:
- Metabolic homeostasis and chronobiology
- Mitochondrial dynamics and function
Background:
- Whole-body energy balance relies on nutrient intake, utilization, bioenergetics, and expenditure, linked to feeding and circadian rhythms.
- Altered feeding and circadian cycles significantly impact systemic metabolism, contributing to disease.
- Mitochondria play a pivotal role in physiological homeostasis, influenced by daily nutrient and light-dark cycles.
Purpose of the Study:
- To summarize the current understanding of mitochondrial remodeling in response to feeding and circadian cycles.
- To provide perspective on the complex signals regulating mitochondrial dynamics.
- To identify knowledge gaps and suggest future research directions.
Main Methods:
- Literature review and synthesis of current research on mitochondrial dynamics.
- Analysis of cell-autonomous and non-cell-autonomous signaling pathways.
- Exploration of diurnal regulation of mitochondrial fission and fusion events.
Main Results:
- Mitochondrial remodeling is intrinsically linked to fed-fast and circadian cycles.
- Both cell-intrinsic and extrinsic factors coordinate mitochondrial dynamics.
- Diurnal regulation of mitochondrial fission/fusion impacts overall mitochondrial output.
Conclusions:
- Mitochondria are central to adapting metabolism to daily rhythms.
- Further research into the regulation of mitochondrial dynamics is needed to understand metabolic health and disease.
- Investigating diurnal mitochondrial remodeling offers new insights into metabolic control.
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