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Fluorescence Lifetime Macro Imager for Biomedical Applications
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Unexcited Light Source Imaging for Biomedical Applications.

Ruihao Ding1, Danqing Liu1, Yu Feng1

  • 1School of Material Science and Chemical Engineering, Harbin University of Science and Technology, 150040, Harbin, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 4, 2023
PubMed
Summary
This summary is machine-generated.

Unexcited light source imaging offers high sensitivity and signal-to-noise ratios for biomedical applications. This review highlights advances in luminescent probes for inflammation, tumor, and infection imaging.

Keywords:
afterglow luminescencebioluminescencechemiluminescencefluorescencephotochemistry

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Luminescence Technologies

Background:

  • Optical imaging is crucial for visualizing physiological processes and disease diagnosis.
  • Unexcited light source imaging (chemiluminescence, bioluminescence, afterglow) offers advantages like no excitation light interference, high sensitivity, and high signal-to-noise ratio.
  • These techniques are gaining traction in biomedical research.

Purpose of the Study:

  • To review the latest advancements in unexcited light source imaging for biomedical applications.
  • To discuss design strategies for luminescent probes to enhance imaging performance.
  • To explore the applications of these technologies in various disease models.

Main Methods:

  • Review of recent literature on unexcited light source imaging technologies.
  • Analysis of design strategies for luminescent probes (brightness, penetration depth, quantum yield, targeting).
  • Examination of applications in inflammation, tumor, liver/kidney injury, and bacterial infection imaging.

Main Results:

  • Unexcited light source imaging demonstrates significant potential due to its inherent advantages.
  • Optimized luminescent probes improve imaging sensitivity and specificity.
  • Successful applications demonstrated in preclinical models for various diseases.

Conclusions:

  • Unexcited light source imaging is a rapidly advancing field with significant potential in medical diagnostics and therapeutics.
  • Continued development of luminescent probes and imaging systems will further expand its clinical utility.
  • Future research should focus on translating these technologies for broader medical applications.