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Investigating the Correlation between Serum Amyloid A and Infarct-Related Artery Patency Prior to Percutaneous

Hao Ji1, Senjiang Chen1, Qingqing Hu1

  • 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Angiology
|July 4, 2023
PubMed

Insights

Serum amyloid A (SAA) predicts infarct-related artery (IRA) patency in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI). Higher SAA levels indicate a greater likelihood of IRA occlusion before PCI.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • Serum amyloid A (SAA) is recognized as a cardiovascular risk factor.
  • SAA may predict infarct-related artery (IRA) patency in ST-elevation myocardial infarction (STEMI) patients.
  • Percutaneous coronary intervention (PCI) is a standard treatment for STEMI.

Purpose of the Study:

  • To investigate the association between pre-PCI SAA levels and IRA patency in STEMI patients.
  • To evaluate SAA as a potential predictor of IRA patency.
  • To determine the diagnostic performance of SAA for IRA patency.

Main Methods:

  • Serum amyloid A (SAA) levels were measured in 363 STEMI patients undergoing PCI.
  • Patients were categorized into occlusion (TIMI 0-2) and patency (TIMI 3) groups based on IRA flow.
  • Receiver operating characteristic (ROC) curve analysis and multivariate logistic regression were employed.

Main Results:

  • Pre-PCI SAA levels were significantly higher in patients with IRA occlusion compared to those with patency.
  • SAA demonstrated good diagnostic performance with an area under the ROC curve (AUC) of .833.
  • SAA was identified as an independent predictor of IRA patency (OR = 1.041, P < .001).

Conclusions:

  • Serum amyloid A (SAA) is a potential predictor of infarct-related artery (IRA) patency in STEMI patients prior to PCI.
  • Elevated SAA levels are associated with IRA occlusion.
  • SAA measurement could aid in risk stratification and treatment decisions for STEMI patients.

Keywords:
ST-segment elevation myocardial infarctioninfarct-related arterypredictorserum amyloid A

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